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Updated: May 16, 2026

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
Published on: June 2, 2023
[Primary squamous cell carcinoma of the thyroid gland]
H Kleinhans1, K W Schmid, T Verse
1Klinik für Hals-, Nasen-, Ohrenheilkunde, Kopf- und Halschirurgie, Asklepios-Klinikum Harburg, Hamburg. dr.kleinhans@gmx.de
Abstract:
Primary squamous cell carcinoma of the thyroid gland is a rare form of cancer. As part of the differential diagnosis, metastases or direct extension from an extra-thyroidal primary tumor must always be ruled out. We report on a 59-year-old patient presenting with a 3.9-cm cold nodule on thyroid scintigraphy. A total thyroidectomy was performed and the final histopathological evaluation revealed an undifferentiated, primary squamous cell carcinoma of the thyroid gland, tumor stage pT2 pN0 (0/56), L0 V0 R0. On the basis of the R0 resection, tumor size and negative nodal status, we recommended regular postoperative follow-up examinations without adjuvant radiochemotherapy.
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