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Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
Published on: April 18, 2025
Dementia and neuroimaging
Federica Agosta1, Francesca Caso, Massimo Filippi
1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, via Olgettina 60, 20132 Milan, Italy.
Abstract:
Early diagnosis of dementing conditions and an accurate monitoring of their progression are important clinical and research goals, especially given the improving prospects of disease-modifying therapies. Neuroimaging has played and is playing an important role in detecting reversible, treatable causes of dementia, and in characterizing the dementia syndromes by demonstrating structural and functional signatures that can aid in their differentiation. Many new imaging techniques and modalities are also available that allow the assessment of specific aspects of brain structure and function, such as positron emission tomography with new ligands, diffusion tensor magnetic resonance imaging (MRI) and functional MRI. In this review, we report the most recent findings from the papers published in the Journal of Neurology that used conventional and advanced neuroimaging techniques for the study of various dementing conditions.
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