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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Serum alkaline phosphatase is a predictor of mortality, myocardial infarction, or stent thrombosis after implantation
Jun-Bean Park1, Do-Yoon Kang, Han-Mo Yang
1Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, 101 DaeHak-ro, JongRo-gu, Seoul 110-744, Republic of Korea.
European Heart Journal
|December 18, 2012
Summary
Higher alkaline phosphatase (ALP) levels predict increased mortality, myocardial infarction, and stent thrombosis in coronary artery disease (CAD) patients after percutaneous coronary intervention (PCI) with drug-eluting stents (DES). This finding highlights ALP as a significant prognostic marker.
Area of Science:
- Cardiovascular Medicine
- Biomarkers
- Interventional Cardiology
Background:
- Alkaline phosphatase (ALP) has been linked to mortality in specific patient groups.
- The prognostic role of ALP in overall coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI) remains unclear.
Purpose of the Study:
- To investigate the prognostic value of serum alkaline phosphatase (ALP) levels.
- To assess ALP's predictive capability in patients with CAD who underwent PCI with drug-eluting stents (DES).
Main Methods:
- Prospective study including 1636 CAD patients who underwent PCI with DES.
- Patients were stratified into tertiles based on baseline ALP levels.
- Outcomes were analyzed after adjusting for confounders, with a median follow-up of 762 days.
Main Results:
- A significant, independent, and dose-dependent association was found between higher ALP tertiles and all-cause mortality (P for trend < 0.0001).
- The highest ALP tertile showed an adjusted hazard ratio (HR) of 4.21 for all-cause mortality compared to the lowest tertile.
- Elevated ALP levels were also associated with increased cardiovascular mortality, myocardial infarction, and stent thrombosis, and correlated with coronary calcification.
Conclusions:
- Higher serum ALP levels are an independent predictor of mortality in CAD patients post-PCI with DES.
- Serum ALP is also a predictor of myocardial infarction and stent thrombosis in this patient population.
- Combined evaluation of ALP and C-reactive protein offers enhanced predictive value.
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