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Variation in the cholesterol/phospholipid ratio in human spermatozoa and its relationship with capacitation
1Department of Obstetrics and Gynaecology, Fukushima Medical College, Japan.
Human Reproduction (Oxford, England)
|January 1, 1990
Abstract:
The cholesterol/phospholipid (C/PL) ratio was determined for spermatozoa from eight men with normal semen parameters. There was a close correlation between the C/PL ratio and the rate of sperm capacitation as assessed by the hamster egg penetration test. A lower C/PL ratio correlated with a faster capacitation time. This supports the notion that the loss or reduction of membrane cholesterol constitutes an important step of capacitation in human spermatozoa.