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Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
SDF-1alpha G801A polymorphism in Southern Iranian patients with colorectal and gastric cancers
Mahboobeh Razmkhah1, Abbas Ghaderi
1Shiraz Institute for Cancer Research, Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Background:
A single nucleotide polymorphism (SNP) in the stromal cell-derived factor-1 (SDF-1) gene at position 801 (G>A) is associated with susceptibility to certain tumors. This study aimed to investigate an association between this SNP and colorectal and gastric cancers in an Iranian population.
Method:
Genotype and allele frequencies of SDF-1 801 G>A were assessed using polymerase chain reaction-restriction fragment length polymorphism in 109 patients with colorectal cancer, 124 with gastric cancer, and 262 normal control volunteers.
Results:
No statistically significant difference was observed in the frequencies of genotypes and alleles between patients and controls (p > 0.05).
Conclusion:
SDF-1 gene polymorphism at position 801 (G>A) was not associated with colorectal and gastric cancers in Southern Iranian patients.
