Related Experiment Video
Updated: May 16, 2026
08:59
Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions
Published on: April 18, 2015
Current concepts in Dupuytren's disease
1Canniesburn Plastic Surgery Unit, Jubilee Building, Royal Infirmary, 84 Castle Street, Glasgow, G4 0SF, UK, stevenjlo@hotmail.com.
Current Reviews in Musculoskeletal Medicine
|December 18, 2012
Summary
Recent Dupuytren's disease research shows injectable collagenase may change treatment. Studies also evaluated needle fasciotomy versus fasciectomy and splinting effectiveness.
Area of Science:
- Hand surgery
- Orthopedic research
- Musculoskeletal disease management
Background:
- Dupuytren's disease is a progressive condition affecting hand function.
- Current management strategies are evolving with new therapeutic options.
- Evidence-based evaluation of recent advancements is crucial for clinical practice.
Purpose of the Study:
- To review and assess therapeutic studies for Dupuytren's disease published between January 2010 and August 2012.
- To evaluate the quality of evidence and strength of recommendations for emerging treatments.
- To discuss the implications of recent findings for clinical practice and future research.
Main Methods:
- Systematic review of therapeutic studies on Dupuytren's disease.
- Assessment of study quality using Jadad and Detsky scales.
- Grading of recommendations based on evidence levels.
Main Results:
- Successful Phase III trials of injectable collagenase (CORD I and II) indicate a potential paradigm shift in treatment.
- Randomized controlled trials provide evidence on needle fasciotomy versus limited fasciectomy.
- The utility of post-operative night-time splinting was evaluated.
Conclusions:
- Injectable collagenase shows promise for radically altering Dupuytren's disease management.
- Evidence supports ongoing debates regarding surgical techniques and post-operative care.
- The concept of clinically important differences is relevant for outcomes research in Dupuytren's disease.
Related Concept Videos
01:31Diabetic Foot Ulcer
Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
01:27Peripheral Artery Disease III: Interprofessional Care
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
01:23Peripheral Artery Disease V: Postoperative Nursing Management
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
01:24Healing II: Complications
Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
01:16Muscles of the Forearm that Move the Hand and Fingers
The muscles of the forearm that move the wrist, hand, and digits are numerous and diverse. They can be classified into two groups based on their location and function — the anterior and posterior compartment muscles.
Anterior Compartment
The anterior compartment muscles originate from the humerus. They primarily function as flexors and are also known as flexor muscles. They typically insert on the carpals, metacarpals, and phalanges. The superficial layer includes the flexor carpi radialis,...
Anterior Compartment
The anterior compartment muscles originate from the humerus. They primarily function as flexors and are also known as flexor muscles. They typically insert on the carpals, metacarpals, and phalanges. The superficial layer includes the flexor carpi radialis,...
01:30Peripheral Artery Disease I: Introduction
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...