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Updated: May 16, 2026
10:52
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Telomere length in mantle cell lymphoma.
Billy Michael Chelliah Jebaraj1, Dirk Kienle, André Lechel
1Department of Internal Medicine III, University of Ulm, Ulm, Germany.
Blood
|December 18, 2012
Summary
Telomere shortening is important in cancer. In mantle cell lymphoma (MCL), telomere length did not predict outcomes, unlike in chronic lymphocytic leukemia (CLL) where short telomeres indicate a poor prognosis.
Area of Science:
- Oncology
- Genetics
Background:
- Telomere shortening is a hallmark of aging and cancer, impacting disease progression.
- Its role varies across different B-cell malignancies.
Purpose of the Study:
- To investigate the prognostic significance of telomere length in mantle cell lymphoma (MCL).
- To compare telomere length dynamics in MCL with chronic lymphocytic leukemia (CLL) and normal B cells.
Main Methods:
- Quantitative PCR (Q-PCR) was used to measure telomere length in 73 MCL, 55 CLL, and 20 normal B-cell samples.
- Telomere length was correlated with clinical and biological features, and patient outcomes.
Main Results:
- Telomere length was highly variable in MCL, with shorter telomeres compared to normal B cells, suggesting dysfunction.
- Unlike in CLL, short telomeres in MCL showed no significant association with clinical features or survival.
- A trend suggested more genomic aberrations with shorter telomeres in MCL.
Conclusions:
- Telomere length is not a prognostic factor in mantle cell lymphoma.
- Telomere length is a significant prognostic marker in chronic lymphocytic leukemia, but not MCL.
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