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Related Experiment Videos

Experimental acute selenium intoxication in lambs.

J B Smyth1, J H Wang, R M Barlow

  • 1Department of Veterinary Pathology, Royal Veterinary College, Hatfield, Herts, U.K.

Journal of Comparative Pathology
|February 1, 1990
PubMed
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Selenium toxicity in lambs can vary significantly between individuals. This study confirms harm to cardiovascular, respiratory, and urinary systems, and reveals new damage to lymphoid tissues.

Area of Science:

  • Veterinary Toxicology
  • Animal Pathology

Background:

  • Selenium is an essential trace element, but excessive intake can lead to toxicity.
  • Sodium selenite is a common source of selenium used in animal nutrition and supplementation.
  • Growing lambs are particularly susceptible to nutritional imbalances and toxic exposures.

Purpose of the Study:

  • To investigate the toxic effects of a specific dose of selenium (5 mg/kg body weight) administered orally and parenterally to growing lambs.
  • To assess the pathological changes induced by selenium intoxication.
  • To correlate selenium distribution within tissues with observed histopathological damage.

Main Methods:

  • Growing lambs were administered 5 mg/kg body weight of selenium as sodium selenite via oral and parenteral routes.

Related Experiment Videos

  • Clinical signs and pathological changes were monitored.
  • Histopathological examination of various organs was performed.
  • A histochemical method was employed to detect and quantify selenium-bonds within tissues.

    • Main Results:

    • Significant individual variation in susceptibility to selenium toxicity and pathological outcomes was observed.
    • Deleterious effects on cardiovascular, respiratory, and urinary systems were confirmed.
    • New evidence of damage to secondary lymphoid tissues in multiple organs was identified.
    • A positive correlation was found between the density of selenium deposits (detected histochemically) and the severity of histopathological changes.
    • Selenium distribution was mapped in tissues with minimal gross or histopathological findings.

    Conclusions:

    • Selenium intoxication in growing lambs exhibits considerable inter-individual variability.
    • The study confirms known toxic effects on vital organ systems and identifies secondary lymphoid tissue as a novel target.
    • Histochemical detection of selenium provides a valuable tool for understanding selenium toxicokinetics and correlating exposure with tissue damage.