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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Related Experiment Video

Updated: May 16, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Cyclodextrin-based nanosponges as drug carriers.

Francesco Trotta1, Marco Zanetti, Roberta Cavalli

  • 1Dipartimento di Chimica. University of Torino, Via Pietro Giuria 7 10125 Torino, Italy.

Beilstein Journal of Organic Chemistry
|December 18, 2012
PubMed
Summary

Cyclodextrin-based nanosponges are versatile, biodegradable nanoparticles. These innovative drug carriers enhance solubility, protect substances, and enable controlled release for nanomedicine applications.

Keywords:
controlled releasecross-linked polymerscyclodextrindrug deliverynanosponges

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Cyclodextrins are cyclic oligosaccharides with a hydrophobic cavity and hydrophilic exterior.
  • Nanosponges are cross-linked cyclodextrin polymers forming a 3D network.
  • Existing drug delivery systems face challenges with solubility, stability, and targeted delivery.

Purpose of the Study:

  • To introduce and characterize cyclodextrin-based nanosponges as a novel drug delivery system.
  • To explore the tunable properties and functionalization potential of these nanosponges.
  • To evaluate their safety and efficacy in drug delivery applications.

Main Methods:

  • Synthesis of cross-linked cyclodextrin polymers into nanostructured networks.
  • Characterization of nanoparticle structure (crystalline/amorphous), shape, and swelling properties.
  • Functionalization of nanosponges with ligands for targeted delivery.
  • Assessment of drug complexation, release kinetics, and in vitro/in vivo toxicity.

Main Results:

  • Cyclodextrin nanosponges exhibit tunable polarity and dimensions via cross-linking.
  • Functionalization allows for site-specific targeting.
  • The material is safe, biodegradable, and well-tolerated in vivo.
  • Nanosponges effectively complex with lipophilic and hydrophilic molecules.
  • Drug release profiles can be modulated for sustained or rapid delivery.

Conclusions:

  • Cyclodextrin-based nanosponges represent a promising platform for drug delivery.
  • They offer solutions for improving solubility of poorly water-soluble drugs.
  • Their versatility supports applications in sustained release and targeted nanomedicine.
  • The tunable nature and safety profile make them attractive for pharmaceutical development.