Related Experiment Video
Updated: May 16, 2026
06:59
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
Novel approaches to surfactant administration
1University Hospital of North Tees and Durham University, Hardwick Road, Stockton-on-Tees, Cleveland, OH TS19 8PE, UK.
Critical Care Research and Practice
|December 18, 2012
Summary
Surfactant replacement therapy is standard for preterm infants with respiratory distress syndrome. Novel noninvasive ventilation methods for surfactant administration are reviewed, offering potential improvements in treatment.
Area of Science:
- Neonatal Medicine
- Pulmonology
- Biomedical Engineering
Background:
- Respiratory distress syndrome (RDS) is a common condition in preterm infants.
- Surfactant replacement therapy (SRT) has been a cornerstone treatment for decades.
- Traditional SRT involves intratracheal administration and mechanical ventilation.
Purpose of the Study:
- To review novel surfactant administration techniques.
- To evaluate the clinical evidence for noninvasive ventilation (NIV) in SRT.
- To explore advancements beyond traditional intratracheal methods.
Main Methods:
- Review of existing literature on SRT and NIV.
- Analysis of clinical studies investigating novel administration routes.
- Synthesis of evidence regarding efficacy and safety.
Main Results:
- NIV approaches are emerging as alternatives to invasive ventilation.
- Specific techniques like INSURE and LISA are being studied.
- Evidence for improved outcomes with NIV is growing but requires further research.
Conclusions:
- Noninvasive ventilation offers promising alternatives for surfactant delivery in preterm infants.
- Further research is needed to optimize NIV techniques and confirm long-term benefits.
- The field is evolving towards less invasive SRT methods.
Related Concept Videos
01:22Drug Delivery: Miscellaneous Routes
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
01:18Additional Routes of Drug Administration
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
01:05Breathing
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
01:27Bioavailability Enhancement: Drug Permeability Enhancement
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
01:23Oral Drug Delivery Systems: Introduction
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
01:23Inhaled Medications
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...