Related Experiment Video
Updated: May 16, 2026
10:10
Robotic Duodenum-preserving Total Pancreatic Head Resection for Intraductal Papillary Mucinous Neoplasms
Published on: April 17, 2026
Primary myeloid sarcoma masquerading as an obstructing duodenal carcinoma
Preeti Narayan1, Vijayashree Murthy, Mu Su
1School of Medicine, St. George's University, Grenada, West Indies.
Case Reports in Hematology
|December 18, 2012
Summary
Myeloid Sarcoma (MS) is a rare cancer affecting extramedullary sites. Gastrointestinal involvement, particularly in the duodenum, is uncommon but should be considered in differential diagnoses, especially with coexisting hematological disorders.
Area of Science:
- Oncology
- Hematology
Background:
- Myeloid Sarcoma (MS) is a rare extramedullary tumor of blast cells.
- It typically occurs with acute myeloid leukemia (AML) or myeloproliferative disorders.
- Gastrointestinal involvement is exceptionally rare, presenting with varied symptoms.
Purpose of the Study:
- To highlight the rarity and diagnostic considerations of duodenal Myeloid Sarcoma.
- To review existing literature and present a case of duodenal MS.
- To discuss the prognosis and therapeutic strategies for MS.
Main Methods:
- Literature review of duodenal Myeloid Sarcoma cases.
- Case report analysis.
Main Results:
- Eight cases of duodenal MS, including the current one, have been reported.
- The mean age of affected patients is 40 years, with a male predominance (M:F ratio 7:1).
- Prognosis appears better for de novo MS compared to cases with coexisting leukemia.
Conclusions:
- Myeloid Sarcoma should be considered in duodenal soft tissue mass differentials, especially with concurrent hematological conditions.
- De novo MS cases may progress to AML, necessitating chemotherapy (e.g., Daunorubicin, Cytarabine).
- The molecular heterogeneity of MS suggests potential for targeted therapies and curative strategies.
Related Concept Videos
01:11Pyloric Obstruction
Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
01:07Intestinal Obstruction II: Pathophysiology
Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
01:25Peptic Ulcer Disease III: Clinical Manifestations and Complications
Duodenal UlcersDuodenal ulcers are the most common form of peptic ulcer disease, presenting with chronic, intermittent epigastric pain. Pain typically appears 2–3 hours after meals, especially when the stomach is empty, often waking patients at night. It is characteristically relieved by food or antacids (“pain–food–relief”). Some patients remain asymptomatic until complications like bleeding or perforation emerge, particularly with NSAID or anticoagulant use.Gastric UlcersGastric ulcers share...