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Updated: May 16, 2026

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
Published on: January 6, 2014
Targeting cancer stem cells via dendritic-cell vaccination
Seagal Teitz-Tennenbaum1, Max S Wicha, Alfred E Chang
1Department of Internal Medicine; University of Michigan; Ann Arbor, MI USA.
Abstract:
Using syngeneic murine tumor models established in immunocompetent hosts, we showed that cancer stem cells are immunogenic and can be selectively targeted by dendritic cell-based vaccines. This new approach induced both humoral and cellular immune responses and conferred significantly superior antitumor immunity as compared with conventional vaccines.
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