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Updated: May 16, 2026

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube

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Published on: April 28, 2020

Double, suicidal intoxication with hydroxycarbamide--a case report.

Wojciech Waldman¹, Piotr Kabata, Jacek Sein Anand

¹Department of Clinical Toxicology, Medical University of Gdańsk. waldman.wojciech@gmail.com

Przeglad Lekarski

|December 19, 2012

Summary

This case report details a rare instance of adult suicidal overdose with hydroxycarbamide (hydroxyurea), an antineoplastic and antisickling agent. The patient experienced no severe complications from the intentional ingestion.

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Area of Science:

Pharmacology
Toxicology
Hematology

Background:

Hydroxycarbamide (hydroxyurea) is a vital medication used for its antineoplastic and antisickling properties.
Essential thrombocythemia is a myeloproliferative neoplasm characterized by elevated platelet counts.

Observation:

A 31-year-old female with essential thrombocythemia ingested hydroxycarbamide twice suicidally.
The first ingestion involved 7.5g hydroxycarbamide with diazepam and alcohol.
The second ingestion involved 10g hydroxycarbamide with paroxetine and alcohol.

Findings:

The patient presented with restlessness and decreased mood.
A transient decrease in leukocyte count was observed after the first overdose.
No significant hematological or biochemical abnormalities were noted after the second overdose.

Implications:

This is the first reported case of acute suicidal intoxication with hydroxycarbamide in an adult.
Highlights the potential for intentional overdose with hydroxycarbamide.
Underscores the importance of monitoring patients with essential thrombocythemia and psychiatric comorbidities.