Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Clinical Significance of Antibiotic Resistance

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

Mechanism of Antibiotic Resistance in MRSA

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...

Defense Against Bacterial Pathogens

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

Staphylococcal Skin Infections

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...

Antimicrobial Effectiveness

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...

Chemical Agents for Microbial Control

Chemical Agents for Microbial Control

Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

'Fall' in vacancies may be result of deliberate policy to cut costs.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2017

Same author

NHS Commissioning Board begins £3m senior level recruitment drive.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2017

Same author

Mid Staffs' £15m deficit sparks financial scrutiny by Monitor.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2017

Same author

Cameron spells out quality forum's.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2017

Same author

Doctors demand better training for nurses in continence care.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2017

Same author

Nurses can lead on reducing litigation claims by avoiding preventable harm.

Nursing management (Harrow, London, England : 1994)·2016

Search research articles

Related Experiment Video

Updated: May 16, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

War on MRSA.

Jennifer Sprinks

Nursing Standard (Royal College of Nursing (Great Britain) : 1987)

|December 19, 2012

Summary

This summary is machine-generated.

A lack of central funding for hand hygiene campaigns risks progress in reducing MRSA and healthcare-associated infections. Experts stress a multifaceted approach to infection control, with the Department of Health asserting that momentum is not being lost.

More Related Videos

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects

Published on: September 27, 2024

Related Experiment Videos

Last Updated: May 16, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects

Published on: September 27, 2024

Area of Science:

Infection Control and Public Health

Background:

Methicillin-resistant Staphylococcus aureus (MRSA) and healthcare-acquired infections (HAIs) pose significant risks in clinical settings.
Progress in reducing these infections is threatened by a decline in focused prevention efforts.

Purpose of the Study:

To evaluate the impact of reduced central funding for hand hygiene campaigns on infection control.
To highlight differing perspectives on infection control strategies and momentum.

Main Methods:

Qualitative assessment based on statements from a patient champion and healthcare professionals.
Review of Department of Health's stance on infection control momentum.

Main Results:

A patient champion identifies a lack of centrally funded hand hygiene campaigns as a threat to reducing MRSA and HAIs.
Healthcare professionals advocate for a multifactorial approach to infection control.
The Department of Health disputes claims of lost momentum in infection control efforts.

Conclusions:

Sustained reduction of MRSA and HAIs requires consistent, centrally supported initiatives like hand hygiene promotion.
Effective infection control necessitates a comprehensive strategy beyond single interventions.
Ongoing evaluation and support are crucial to maintain progress in combating healthcare-associated infections.