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Using Adhesive Patterning to Construct 3D Paper Microfluidic Devices
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Method for fabrication of paper-based microfluidic devices by alkylsilane self-assembling and UV/O3-patterning.

Qiaohong He1, Cuicui Ma, Xianqiao Hu

  • 1Institute of Microanalytical Systems, Department of Chemistry, Zhejiang University, Zijin'gang Campus, Hangzhou 310058, China. heqh@zju.edu.cn

Analytical Chemistry
|December 19, 2012
PubMed
Summary

Researchers developed a simple method for creating paper-based microfluidic devices using hydrophobic silane treatment and deep UV-lithography. This technique enables precise patterning of hydrophilic channels on hydrophobic paper for various assays.

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Area of Science:

  • Materials Science
  • Microfluidics
  • Analytical Chemistry

Background:

  • Paper-based microfluidic devices offer a low-cost platform for diagnostics.
  • Controlling surface wettability is crucial for defining fluid flow in microchannels.
  • Existing fabrication methods can be complex or expensive.

Purpose of the Study:

  • To develop a facile and novel method for fabricating paper-based microfluidic devices.
  • To create well-defined hydrophilic channels and hydrophobic barriers on paper substrates.
  • To demonstrate the utility of these devices for chemical assays.

Main Methods:

  • Hydrophobic modification of filter paper using octadecyltrichlorosilane (OTS).
  • Deep UV-lithography with a patterned quartz mask to selectively alter surface wettability.
  • Surface characterization using contact angle measurements, XPS, and ATR-FT-IR spectroscopy.

Main Results:

  • Achieved a highly hydrophobic paper surface (contact angle ~125°) after OTS coupling.
  • Generated well-defined hydrophilic microchannels (233 ± 30 μm) and hydrophobic barriers (137 ± 21 μm).
  • Successfully demonstrated colorimetric nitrite assays using the fabricated paper microfluidic devices.

Conclusions:

  • The presented method provides a straightforward approach for fabricating patterned paper microfluidic devices.
  • The technique allows for precise control over channel geometry and surface properties.
  • These devices are suitable for sensitive and low-cost chemical analysis.