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MSRA polymorphism is associated with the risk of rheumatoid arthritis in a Chinese population

Y Zhang1, H Zhang, C Zhuang

  • 1Department of Ophthalmology, Affiliated Hospital of Suzhou University, Changzhou No. 4 People's Hospital, Changzhou, China.

Scandinavian Journal of Rheumatology
|December 19, 2012
PubMed
Abstract

Insights

The MSRA rs10903323 G/A polymorphism increases rheumatoid arthritis (RA) risk in the Chinese population. This genetic variant is particularly associated with RA development in male, older, CRP-positive, and anti-CCP-negative patients.

Area of Science:

  • Genetics
  • Rheumatology
  • Immunology

Background:

  • Rheumatoid arthritis (RA) is an autoimmune disease with complex genetic factors.
  • Receptor activator of methionine sulfoxide reductase A (MSRA) and receptor activator of nuclear factor-kappa B (NF-κB) ligand (RANKL) are implicated in RA pathogenesis.
  • Understanding the role of genetic polymorphisms in RA susceptibility is crucial for diagnosis and treatment.

Purpose of the Study:

  • To investigate the association between MSRA rs10903323 G/A and RANKL rs7984870 C/G polymorphisms and rheumatoid arthritis (RA) risk in a Chinese population.
  • To determine if specific genotypes of MSRA and RANKL are linked to increased susceptibility to RA.
  • To explore potential correlations between these polymorphisms and clinical characteristics of RA patients.

Main Methods:

  • A case-control study involving 329 RA patients and 697 healthy controls from a Chinese population.
  • Genotyping of MSRA rs10903323 G/A and RANKL rs7984870 C/G polymorphisms using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS).
  • Statistical analysis to assess the association between genotypes and RA risk, including stratification by gender, age, CRP, and anti-CCP status.

Main Results:

  • The MSRA rs10903323 G/A polymorphism was significantly associated with an increased risk of RA.
  • Specifically, the GA genotype and the GA/AA genotypes (dominant model) showed increased susceptibility to RA.
  • No significant association was found between the RANKL rs7984870 C/G polymorphism and RA risk.
  • Stratification analysis revealed that the MSRA rs10903323 GA genotype conferred a higher RA risk in male, older, CRP-positive, and anti-CCP-negative individuals.

Conclusions:

  • The MSRA rs10903323 G/A variant allele is a risk factor for rheumatoid arthritis (RA) development in the Chinese population.
  • This genetic association is particularly pronounced in specific subgroups, including males, older individuals, and those who are CRP-positive and anti-CCP-negative.
  • The findings highlight the potential role of MSRA gene polymorphisms in RA pathogenesis and suggest the need for further research into targeted genetic screening.

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