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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

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Related Experiment Video

Updated: May 16, 2026

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
13:47

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

Published on: March 29, 2019

Targeting epigenetics in nervous system disease.

Ruihan Zhang1, Junyan Lu, Xiangqian Kong

  • 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

CNS & Neurological Disorders Drug Targets
|December 19, 2012
PubMed
Summary

Epigenetic modifications regulate gene expression crucial for nervous system development and function. Targeting epigenetic enzymes offers promising therapeutic strategies for various brain disorders.

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Last Updated: May 16, 2026

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
13:47

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

Published on: March 29, 2019

Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins
09:56

Epigenetic Engineering of K562 Cells: Dual-Vector Episomal Strategy for Stable Targeted DNA Methylation using dCas9-DNMT3A and -HDAC1 Fusion Proteins

Published on: October 31, 2025

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Epigenetics governs gene expression through chemical modifications of chromatin without altering DNA sequence.
  • These modifications are vital for nervous system development and function.
  • Dysregulation of epigenetic enzymes is linked to neurological and psychiatric disorders.

Purpose of the Study:

  • To review the association between epigenetic mechanisms and nervous system disorders.
  • To discuss recent advancements in drug discovery targeting epigenetic regulators for neurological conditions.

Main Methods:

  • Literature review of epigenetic mechanisms in the nervous system.
  • Analysis of current drug discovery efforts targeting epigenetic regulators.

Main Results:

  • Epigenetic enzymes play a critical role in modulating gene expression in the brain.
  • Aberrant epigenetic enzyme activity is implicated in neurodevelopmental disorders, brain cancer, neurodegenerative diseases, and mental illnesses.
  • Epigenetic regulators are emerging as viable therapeutic targets for nervous system disorders.

Conclusions:

  • Epigenetic mechanisms are fundamental to nervous system health and disease.
  • Targeting epigenetic regulators holds significant therapeutic potential for a range of brain disorders.
  • Further research into epigenetic drug discovery is warranted for treating neurological conditions.