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Related Experiment Video

Updated: May 16, 2026

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Published on: September 18, 2016

IL-23 in colitis: targeting the progenitors.

Ce Tang¹, Yoichiro Iwakura

¹Research Institute for Biomedical Sciences, Tokyo University of Science, Yamazaki 2669, Noda-shi, Chiba, Japan.

|December 19, 2012

Summary

Interleukin-23 (IL-23) dysregulates hematopoietic stem and progenitor cells, contributing to inflammatory bowel disease (IBD) development. This finding offers new insights into IBD pathogenesis and potential therapeutic targets.

Area of Science:

Immunology
Gastroenterology
Stem Cell Biology

Background:

Inflammatory bowel disease (IBD) encompasses chronic gastrointestinal inflammation.
Understanding the cellular and molecular drivers of IBD pathogenesis is crucial for developing effective treatments.

Discussion:

Griseri et al. demonstrate that Interleukin-23 (IL-23) signaling disrupts the normal function of hematopoietic stem and progenitor cells (HSPCs).
This dysregulation of HSPCs by IL-23 is shown to be a key factor in the development of experimental models of IBD.
The study highlights a novel mechanism linking innate immune signaling to stem cell dysfunction in the context of chronic gut inflammation.

Key Insights:

IL-23 plays a significant role in modulating HSPC behavior.
Aberrant HSPC function driven by IL-23 contributes directly to IBD pathology.

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Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

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Published on: January 25, 2017

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Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

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Published on: September 18, 2016

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

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Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

This research identifies a critical link between immune mediators and stem cell populations in inflammatory diseases.

Outlook:

Further investigation into IL-23-HSPC interactions may reveal new therapeutic strategies for IBD.
Targeting the IL-23 pathway could offer a novel approach to managing IBD by restoring stem cell homeostasis.
This work opens avenues for exploring stem cell-based therapies in conjunction with immune modulation for IBD treatment.