Drug-glycosidation and drug development

Area of Science:

• Medicinal Chemistry
• Pharmacology
• Drug Delivery

Background:

• Achieving targeted drug delivery with minimal concentration and side effects is an ideal pharmaceutical goal.
• Drug targeting strategies aim to enhance therapeutic efficacy at the desired site of action.

Purpose of the Study:

• To review the approach of preparing synthetic drug glycosides for oral administration and targeted drug delivery.
• To explore the diverse biological activities of synthetic drug glycosides.
• To discuss synthetic methodologies for various glycoside types.

Main Methods:

• Preparation of synthetic glycosides of target drugs.
• Oral administration of drug glycosides.
• Enzymatic release of active drug in the colonic region.
• Review of synthetic approaches for O-, C-, N-, and S-glycosides.

Main Results:

• Synthetic drug glycosides can be orally administered and release active drugs enzymatically in the colon.
• Successful examples of this drug targeting approach have been documented.
• Synthetic drug glycosides exhibit various biological activities, including antineoplastic, antidiabetic, and anti-inflammatory properties.

Conclusions:

• Synthetic drug glycosides represent a promising strategy for targeted oral drug delivery.
• These compounds offer a dual benefit of drug targeting and intrinsic pharmacological activity.
• Further research into synthetic glycosides can unlock new therapeutic applications.