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Related Experiment Videos

Clostridium difficile-associated diarrhea after norfloxacin.

E D Ehrenpreis1, M W Lievens, R M Craig

  • 1Department of Medicine, Northwestern University Medical School, Chicago, Illinois.

Journal of Clinical Gastroenterology
|April 1, 1990
PubMed
Summary

Although quinolone antibiotics are considered low risk, a patient developed Clostridium difficile diarrhea while taking norfloxacin. This case highlights the potential for quinolone antibiotics to cause C. difficile-associated diarrhea.

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Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • Quinolone antibiotics are broad-spectrum antimicrobials.
  • Clostridium difficile is an opportunistic pathogen causing diarrhea.
  • Quinolones are theoretically low risk for C. difficile overgrowth.

Observation:

  • A patient developed C. difficile-associated diarrhea.
  • The patient was receiving norfloxacin, a quinolone antibiotic.

Findings:

  • This case challenges the assumption of low risk for quinolones.
  • Norfloxacin may predispose patients to C. difficile-induced diarrhea.

Implications:

  • Clinicians should consider C. difficile risk with all antibiotics, including quinolones.

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  • Further research is needed on the specific mechanisms of quinolone-induced C. difficile diarrhea.