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Updated: May 15, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Catalytic Nazarov reaction of aryl vinyl ketones via binary acid strategy
Zhi-Guo Xi1, Lihui Zhu, Sanzhong Luo
1Department of Chemistry and State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin, 300071, China.
Abstract:
We describe herein a viable binary acid strategy for the catalytic Nazarov reaction of aryl vinyl ketones. Simply combining a Lewis acid and a Brønsted acid led to a dramatic enhancement of the catalytic activity in the Nazarov reaction of aryl vinyl β-ketoesters. The obtained optimal binary acid catalyst In(OTf)(3)/diphenyl phosphoric acid (DPP) can be applied to a range of aryl vinyl ketones with good activity. A trend of reactivity has also been summarized on the basis of mapping of the substituents.
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