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Updated: May 15, 2026

Computational Prediction of Amino Acid Preferences of Potentially Multispecific Peptide-Binding Domains Involved in Protein-Protein Interactions
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Assessing the preferred solution conformation of an interacting sense-antisense (complementary) peptide pair

James R Pullen1, John Dalmaris, Stefano A Serapian

  • 1Imperial College Genetic Therapies Centre, Department of Chemistry, Flowers Building, Armstrong Road, Imperial College London, London SW7 2AZ, UK.

Bioorganic & Medicinal Chemistry Letters
|December 19, 2012
PubMed
Summary

Sense and antisense peptides interact specifically, likely through side-chain contacts. This study used NMR spectroscopy and molecular modeling to support this peptide interaction hypothesis.

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