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The linkage between inflammation and Type 2 diabetes mellitus
Nathália G Cruz1, Lirlândia P Sousa, Marinez O Sousa
1Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Diabetes Research and Clinical Practice
|December 19, 2012
Summary
Type 2 diabetes (DM2) involves insulin resistance and inflammation. This review explores how gene variations in inflammatory cytokines link to higher inflammation markers and chronic DM2 complications.
Area of Science:
- Endocrinology and Metabolism
- Immunology
Background:
- Type 2 diabetes mellitus (DM2) is a major chronic disease with significant morbidity and mortality.
- DM2 is characterized by insulin resistance and impaired insulin secretion.
- Obesity is a key environmental factor, promoting insulin resistance and adipose tissue inflammation.
Purpose of the Study:
- To review the association between genetic polymorphisms in inflammatory cytokines and DM2.
- To discuss the role of elevated pro-inflammatory markers in DM2 pathology.
Main Methods:
- Literature review focusing on genetic associations and inflammatory markers in DM2.
- Analysis of studies investigating gene polymorphisms related to cytokines.
Main Results:
- Polymorphisms in inflammatory cytokine genes are linked to DM2 development.
- Increased levels of pro-inflammatory markers are associated with DM2 and its complications.
Conclusions:
- Genetic variations in inflammatory cytokines play a role in DM2 pathogenesis.
- Inflammation is a critical component of DM2, influencing insulin resistance and disease progression.
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