Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Embryonic Stem Cells00:57

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of cone-beam computed tomography image quality on artificial intelligence-driven three-dimensional tooth segmentation and evaluation of external apical root resorption.

The Angle orthodontist·2026
Same author

Geometric morphometrics based diagnostic model for Skeletal Class III patients.

Communications medicine·2026
Same author

Orthodontic Treatment and External Apical Root Resorption: A Study on the Worldwide Prevalence - A Scoping Review.

Turkish journal of orthodontics·2026
Same author

Clinical Burden of Carbapenemase-Producing Enterobacterales in Spain: A Multicenter Retrospective Study from Five Hospitals.

Infection and drug resistance·2026
Same author

Modified CAMBRA Protocol for Caries Risk Assessment in Children Aged 6 to 14 Years.

Dentistry journal·2025
Same author

Genetic and Molecular Determinants of Familial Transmission of Skeletal Malocclusions.

Orthodontics & craniofacial research·2025
Same journal

Surface properties of irradiated and non-irradiated dentin following pH cycling and fluoride toothpaste exposure: An in vitro study.

Archives of oral biology·2026
Same journal

CircSSRP1 regulates SMAD3 to affect proliferation and apoptosis of human embryonic palatal mesenchymal cells in nonsyndromic cleft lip with or without cleft palate by sponging miR-708-5p.

Archives of oral biology·2026
Same journal

Development of models of preclinical stage 2 bisphosphonate-related osteonecrosis of the jaw in non-rodent mammals using zoledronate: A systematic review.

Archives of oral biology·2026
Same journal

Impact of lifestyle factors on salivary nitrite and nitrate concentrations in overweight/obese individuals.

Archives of oral biology·2026
Same journal

Effects of hypoxia and compressive stress on the expression of angiogenic factors in dental pulp cells.

Archives of oral biology·2026
Same journal

Occlusal abnormalities and temporomandibular joint osteoarthritis: A narrative review of cross-scale mechanical-metabolic-immune mechanisms.

Archives of oral biology·2026
See all related articles

Related Experiment Video

Updated: May 15, 2026

Primary Culture of Dental Pulp Stem Cells
03:45

Primary Culture of Dental Pulp Stem Cells

Published on: May 5, 2023

Stem cells in current paediatric dentistry practice.

Alejandro Iglesias-Linares1, Rosa-María Yáñez-Vico, Elena Sánchez-Borrego

  • 1Paediatric Dentistry, Orthodontics and Dentofacial Orthopedics, School of Dentistry, University of Seville, Spain. aiglesiaslinares@us.es

Archives of Oral Biology
|December 19, 2012
PubMed
Summary
This summary is machine-generated.

New regenerative endodontic protocols and tissue engineering advance treatment for immature teeth. Stem cell therapy shows promise for enhancing apical regeneration and root development, offering new clinical possibilities.

More Related Videos

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth
02:33

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth

Published on: May 17, 2024

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
14:52

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Published on: November 24, 2012

Related Experiment Videos

Last Updated: May 15, 2026

Primary Culture of Dental Pulp Stem Cells
03:45

Primary Culture of Dental Pulp Stem Cells

Published on: May 5, 2023

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth
02:33

Isolation, Culture, and Characterization of Dental Pulp Stem Cells from Human Deciduous and Permanent Teeth

Published on: May 17, 2024

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods
14:52

Isolation, Characterization and Comparative Differentiation of Human Dental Pulp Stem Cells Derived from Permanent Teeth by Using Two Different Methods

Published on: November 24, 2012

Area of Science:

  • Endodontics
  • Regenerative Medicine
  • Tissue Engineering
  • Stem Cell Therapy

Background:

  • Traditional treatments for immature teeth with pulp involvement have limitations in achieving complete apical root development.
  • Clinical decisions for immature teeth (apexogenesis vs. apexification) depend on pulp vitality, but recent evidence challenges established protocols.
  • The growing body of literature necessitates a summary of biological bases for current advances in apical regeneration.

Purpose of the Study:

  • To critically review and summarize recent advancements in apical regeneration for immature teeth.
  • To explore the biological basis of current clinical progress in regenerative endodontics.
  • To highlight the role of stem cell therapy in future pulp regenerative protocols.

Main Methods:

  • Critical review of scientific literature on regenerative endodontic treatment and tissue engineering.
  • Analysis of recent clinical and molecular advances in apical regeneration.
  • Focus on stem cell-based therapies and their application in immature permanent teeth.

Main Results:

  • New protocols and tissue engineering technologies are transforming regenerative endodontic treatment.
  • Stem cell therapy presents a promising avenue for achieving successful apical regeneration and root development.
  • Current research questions traditional approaches, emphasizing the need for updated clinical strategies.

Conclusions:

  • Regenerative endodontics, particularly with stem cell therapy, offers a paradigm shift for treating immature teeth.
  • Understanding the biological mechanisms is crucial for advancing pulp regenerative protocols.
  • Future clinical success hinges on integrating stem cell therapy into endodontic practice.