Related Experiment Video
Updated: May 15, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
Published on: March 31, 2019
C-terminal region of HBx is crucial for mitochondrial DNA damage
Seung-Youn Jung1, Yung-Jin Kim
1Department of Molecular Biology, Pusan National University, Busan 609-735, Republic of Korea.
Abstract:
HBx is strongly associated with hepatocellular carcinoma development through transcription factor activation and reactive oxygen species (ROSs) production. However, the exact role of HBx during hepatocellular carcinogenesis is not fully understood. Recently, it was reported that C-terminal truncated HBx is associated with tumor metastasis. In the present study, we confirmed that the C-terminal region of HBx is required for ROS production and 8-oxoguanine (8-oxoG) formation, which is considered as a reliable biomarker of oxidative stress. These results suggest ROS production induced by the C-terminal region of HBx leads to mitochondrial DNA damage, which may play a role in HCC development.
Related Concept Videos
Animal Mitochondrial Genetics
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Fixing Double-strand Breaks
DNA Helicases
Replication in Eukaryotes
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
DNA Damage can Stall the Cell Cycle

