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Published on: January 7, 2011
The polymorphisms of the MBL2 and MIF genes associated with Pediatric Cochlear Implant Patients
Elif Baysal1, Sibel Oguzkan-Balci, Orhan Tunc
1Gaziantep University, Faculty of Medicine, Department of Otolaryngology, 27060. Sahinbey, Gaziantep, Turkey. baysalelif@yahoo.com
Objectives:
Mannose-binding lectin and macrophage migration inhibitory factor gene polymorphisms are associated with several acute/chronic autoimmune or inflammatory diseases. The aim of this study was to investigate if there was any association between mannose-binding lectin 2 (MBL2) and macrophage migration inhibitory factor (MIF) gene polymorphisms and profound congenital sensorineural hearing loss in children who underwent cochlear implantation.
Methods:
A total of 62 patients with congenital hearing loss and 80 age- and sex-matched healthy controls were evaluated for codon 54 A/B polymorphisms in MBL2 and the-173 G/C polymorphism in MIF by using the polymerase chain reaction and restriction fragment length polymorphism method.
Results:
The frequency of the BB genotype of MBL2 and MIF -173 GC genotype were statistically significantly higher in the patient group than in the controls (p=0.0127, p=0.0408, respectively).
Conclusion:
In this study, we found that a subject who is homozygous for the variant allele B of codon 54 of the MBL2and heterozygous for variant allele C of -173 MIF has a risk factor for sensorineural hearing loss.
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