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Updated: May 15, 2026

Finger-stick Blood Sampling Methodology for the Determination of Exercise-induced Lymphocyte Apoptosis
Published on: February 24, 2011
Acute resistance training affects cell surface markers for apoptosis and migration in CD4⁺ and CD8⁺ lymphocytes
G B Pereira1, J Prestes, R A Tibana
1Programa de Pós-Graduação em Ciências, Fisiológicas da Universidade Federal de São Carlos, São Carlos, São Paulo, Brazil. guifisiologia@gmail.com
Abstract:
The purpose of the present study was to examine the acute effects of resistance training (RT) on CD4⁺ and CD8⁺ T lymphocytes apoptosis (annexin V⁺) and migration (CX₃CR1). Twelve subjects performed two RT sessions (3 sets of 9 exercises) with 1 min (Hyper-1) and 3 min (Hyper-3) of rest-interval length between sets and exercises. CD4⁺ and CD8⁺ cells count displayed no change following Hyper-1 and Hyper-3. There was an increase in the percentage of CD4⁺ positive for annexin V⁺ and CX₃CR1⁺ immediately after and 24 h post Hyper-1. Percentage of CD4⁺ positive for annexin V⁺ increased 2 and 24 h post Hyper-3, and decreased after CXCR1⁺ for the same time-points. There was an increase in CD8⁺ positive for annexin V⁺ and CX₃CR1⁺ immediately after, 2 and 24 h post Hyper-1 and Hyper-3, while no differences were found between Hyper-1 and Hyper-3. Acute RT increase the apoptosis and migration of CD4⁺ and CD8⁺ lymphocytes even 24h after exercise, with minimal effects of rest-interval length.
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