Torching the Haystack: modelling fast-fail strategies in drug development
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Updated: May 15, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
Dennis W Lendrem1, B Clare Lendrem
1Institute of Cellular Medicine, University of Newcastle upon Tyne, United Kingdom. dennis.lendrem@newcastle.ac.uk
Abstract:
By quickly clearing the development pipeline of failing or marginal products, fast-fail strategies release resources to focus on more promising molecules. The Quick-Kill model of drug development demonstrates that fast-fail strategies will: (1) reduce the expected time to market; (2) reduce expected R&D costs; and (3) increase R&D productivity. This paper outlines the model and demonstrates the impact of fast-fail strategies. The model is illustrated with costs and risks data from pharmaceutical and biopharmaceutical companies.
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