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Updated: May 15, 2026
Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
Published on: August 2, 2021
Practical considerations in the development and refinement of subcallosal cingulate white matter deep brain
Patricio Riva-Posse1, Paul E Holtzheimer, Steven J Garlow
1Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Background:
Deep brain stimulation has been investigated in the past decade as a viable intervention for treatment-resistant depression.
Methods:
Several anatomic targets have been tested, with the most extensive published experience found for the subcallosal cingulate (SCC) white matter.
Results:
This article reviews the current state of clinical research of SCC deep brain stimulation for treatment-resistant depression, including an overview of the rationale for targeting SCC, practical considerations for subject recruitment and evaluation, surgical planning, and stimulation parameters.
Conclusion:
Clinical management of patients in the initial and long-term naturalistic phases of treatment, including the potential role for psychotherapeutic rehabilitation, is discussed.
