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Updated: May 15, 2026

Quantitative Analysis of Dietary Vitamin A Metabolites in Murine Ocular and Non-Ocular Tissues Using High-Performance Liquid Chromatography
Published on: December 27, 2024
Protective role of the vitamin D receptor
Lina Yang1, Jianfei Ma, Xiuli Zhang
1Department of Nephrology, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning, PR China.
Abstract:
Vitamin D receptor (VDR) is found in most tissues, not just those participating in the classic actions of vitamin D such as bone, gut, and kidney. The nonclassic actions are therefore potential targets for the active metabolite of vitamin D, 1,25(OH)₂D₃. This review is intended to highlight the actions of VDR in role of protection. Medline is searched for articles describing actions of VDR on secondary hyperparathyroidism, diabetic nephropathy, hypertension and atherosclerosis. VDR exerts its protective activities through the following mechanisms: inhibition of renin-angiotensin system (RAS); regulation of proliferation and differentiation; reduction of proteinuria; anti-inflammation and anti-fibrosis. The nonclassic actions of VDR provide a number of potential new clinical applications for 1,25(OH)₂D₃ and its analogs. We believe 1,25(OH)₂D₃/VDR can be of particular value in the prevention of kidney-related diseases.
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