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Related Experiment Video

Updated: May 15, 2026

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

Biosocial processes predicting multisystemic therapy treatment response.

Stacy R Ryan¹, Patricia A Brennan, Phillippe B Cunningham

¹Emory University, Department of Psychology, 36 Eagle Row #367, Atlanta, GA 30322, United States. ryansr@uthscsa.edu

Biological Psychology

|December 19, 2012

Summary

This summary is machine-generated.

High testosterone and deviant peer affiliation in adolescent boys predict poorer outcomes in Multisystemic Therapy (MST), indicating these factors influence aggression and delinquency during treatment.

Related Experiment Videos

Last Updated: May 15, 2026

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

Area of Science:

Adolescent Psychology
Behavioral Science
Endocrinology

Background:

Adolescent externalizing behaviors like aggression and delinquency are significant concerns.
Predicting treatment outcomes for adolescent boys is crucial for effective interventions.
Understanding the interplay of biological and social factors is key.

Purpose of the Study:

To investigate biological (testosterone) and social (deviant peer affiliation) predictors of treatment outcomes.
To examine these factors' impact on adolescent boys undergoing Multisystemic Therapy (MST).
To assess changes in aggression and delinquency during MST.

Main Methods:

Longitudinal study involving 112 adolescent boys and their caregivers.
Assessed testosterone levels and deviant peer affiliation at treatment onset.
Measured aggression and delinquency at onset, mid-treatment, and end-of-treatment using caregiver reports.
Employed growth curve analyses to examine treatment trajectories.

Main Results:

A combination of high testosterone and high deviant peer affiliation at treatment onset predicted less improvement.
Adolescent boys with high levels of both factors showed smaller declines in aggression and delinquency.
These findings highlight the combined influence of biological and social factors on treatment response.

Conclusions:

Testosterone plays a significant role in predicting future externalizing behaviors in adolescents.
Early identification of high testosterone and deviant peer affiliation may inform treatment adjustments.
Results offer novel insights into the complex etiology of adolescent behavioral issues.