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Updated: May 15, 2026

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
Published on: September 20, 2018
Behavioral functioning in youth with inflammatory bowel disease: perceived barriers as mediator of medication
Bonney Reed-Knight1, Jeffery D Lewis, Ronald L Blount
1Department of Psychology, University of Georgia, Athens, GA 30602-3013, USA. bonreed@uga.edu
Objectives:
To examine the relationship between behavioral functioning specific to levels of attention and conduct problems and prescription medication adherence in youth with inflammatory bowel disease (IBD), and examine the mediational role of perceived barriers to adherence. Identifying potentially malleable factors associated with poor adherence such as behavioral functioning and barriers may guide treatment.
Methods:
85 adolescents with IBD and their parents completed measures of adherence, attention and conduct problems, and barriers. To examine mediation models, indirect effects were tested using bootstrapping procedures outlined by Preacher & Hayes (2004, 2008).
Results:
The majority of participants reported normative levels of attention and conduct problems. Higher levels of attention problems, conduct problems, and barriers were negatively associated with adherence. Bootstrapping procedures indicated that barriers mediated the effects of behavioral functioning on adherence.
Conclusions:
Barriers may be a proximal factor contributing to the relationship between everyday behavioral functioning and adherence in youth with IBD.
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