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Updated: May 15, 2026

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

Leukemia cutis.

Angoori G Rao¹, Indira Danturty

¹Department of Dermatology, SVS Medical College and Gandhi Medical College, Hyderabad, India.

Indian Journal of Dermatology

|December 19, 2012

Summary

This summary is machine-generated.

Leukemia cutis, a rare skin manifestation of acute myeloid leukemia (AML), presents as neoplastic leukocyte infiltration. This case highlights AML-M2 with leukemia cutis in a 50-year-old woman presenting with widespread cutaneous nodules.

Keywords:

Auer rods leukemia cutis myeloperoxidase

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Assessment of the Metabolic Profile of Primary Leukemia Cells

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Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Quantifying Leukocyte Egress via Lymphatic Vessels from Murine Skin and Tumors

Published on: January 7, 2019

Area of Science:

Dermatology
Hematology
Oncology

Background:

Leukemia cutis involves neoplastic leukocyte infiltration into the skin, potentially preceding or accompanying systemic leukemia.
It manifests as clinically identifiable cutaneous lesions.

Purpose of the Study:

To report a rare case of leukemia cutis.
To describe the clinical and pathological features of acute myeloid leukemia with skin involvement.

Main Methods:

A case study of a 50-year-old woman with asymptomatic multiple cutaneous nodules.
Peripheral blood smear analysis revealed elevated white blood cell count with abnormal cells (myeloblasts, promyelocytes, myelocytes) and Auer rods.
Bone marrow aspiration showed increased myeloblasts with maturation arrest.
Immunohistochemistry confirmed myeloperoxidase-positive cells, negative for CD20 and CD3.

Main Results:

The patient presented with multiple asymptomatic, hyperpigmented cutaneous nodules and plaques.
Peripheral smear showed 70,000 TLC with 40% myeloblasts, 8% promyelocytes, and 39% myelocytes.
Bone marrow biopsy confirmed increased myeloblasts with maturation arrest.
Immunohistochemistry was consistent with AML-M2 with leukemia cutis.

Conclusions:

Leukemia cutis is a rare but significant manifestation of acute myeloid leukemia.
This case underscores the importance of considering leukemia cutis in the differential diagnosis of unexplained cutaneous lesions, particularly in the context of hematological abnormalities.