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Modulation of myocardial contraction by peroxynitrite
Mark J Kohr1, Steve R Roof, Jay L Zweier
1Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University Columbus, OH, USA ; Division of Cardiovascular Pathology, Department of Pathology, Johns Hopkins University Baltimore, MD, USA.
Frontiers in Physiology
|December 19, 2012
Summary
Peroxynitrite, a potent oxidant, significantly impacts heart muscle function. This review explores how peroxynitrite regulates heart contraction, focusing on calcium handling and cellular signaling in health and disease.
Area of Science:
- Cardiovascular Physiology
- Oxidative Stress Biology
Background:
- Peroxynitrite is an increasingly recognized modulator of cardiac function.
- Understanding its role is crucial for addressing cardiovascular diseases.
Purpose of the Study:
- To review the regulation of myocardial contraction by peroxynitrite.
- To emphasize cardiomyocyte calcium handling, signaling pathways, and protein targets.
Main Methods:
- Literature review of peroxynitrite's role in myocardial function.
- Analysis of studies on calcium handling and signaling pathways.
- Identification of protein end-targets affected by peroxynitrite.
Main Results:
- Peroxynitrite significantly influences myocardial contraction.
- Key effects are observed in cardiomyocyte calcium handling.
- Specific signaling pathways and protein targets are modulated.
Conclusions:
- Peroxynitrite plays a critical role in myocardial function during health and disease.
- Further research into peroxynitrite's mechanisms can inform therapeutic strategies.
Keywords:
Ca2+cAMP-dependent protein kinasemyocytenitric oxide synthaseperoxynitriteprotein phosphatase 2aMore Related Videos
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