Related Experiment Video
Updated: May 15, 2026
Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion
Published on: February 24, 2021
[Advance in the research of platelet-rich plasma in burn treatment]
1Department Burns and Plastic Surgery, Southeast Hospital Affiliated to Xiamen University, Zhangzhou 363000, China.
Abstract:
Platelet-rich plasma (PRP) is the plasma derived from the repeatedly centrifuged whole blood, and it contains high concentration of platelets. The growth factors and concentrated platelets in PRP play important roles in proliferation, division, and differentiation of cells, and wound repair. In the past, PRP was used in the treatment of bone fracture, bone defect, soft tissue injury, and refractory wound. In recent years, it had been used in burn treatment, but it provoked some disputes. This article reviews the advance in the research of PRP in burn treatment and discusses the problems in its clinical application.
Related Concept Videos
01:22Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
01:22Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...