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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
Phosphoinositides and PIPs01:42

Phosphoinositides and PIPs

Phosphoinositides are a group of phospholipids containing a glycerol backbone with two fatty acid chains and a phosphate attached to a myoinositol sugar ring. The inositol head group extends into the cytoplasm, where it is modified by adding phosphate groups to form phosphatidylinositol phosphates or PIPs.
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

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Related Experiment Video

Updated: May 15, 2026

The MPLEx Protocol for Multi-omic Analyses of Soil Samples
10:12

The MPLEx Protocol for Multi-omic Analyses of Soil Samples

Published on: May 30, 2018

Microproteins (miPs) - the next big thing.

Stephan Feller1

  • 1Biological Systems Architecture Group, Department of Oncology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DS, United Kingdom. stephan.feller@imm.ox.ac.uk.

Cell Communication and Signaling : CCS
|December 20, 2012
PubMed
Summary

Microproteins are emerging as a significant new area of research, poised to become a major focus in scientific publications. This field offers exciting new avenues for discovery, moving beyond current hot topics.

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Related Experiment Videos

Last Updated: May 15, 2026

The MPLEx Protocol for Multi-omic Analyses of Soil Samples
10:12

The MPLEx Protocol for Multi-omic Analyses of Soil Samples

Published on: May 30, 2018

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery
13:00

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery

Published on: April 17, 2012

An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genomics

Background:

  • Established research areas like induced pluripotent stem cells (iPS cells), small non-coding RNAs (sncRNAs), chromatin modification, and cancer stem cells are experiencing diminishing publication novelty.
  • The scientific community constantly seeks groundbreaking fields for high-impact publications.

Purpose of the Study:

  • To identify and propose the next major 'hot topic' in biomedical research.
  • To highlight microproteins as a rapidly advancing and promising field.

Main Methods:

  • Literature review and trend analysis of recent scientific publications.
  • Expert opinion and predictive analysis of emerging research fronts.

Main Results:

  • Analysis indicates a declining trend in the novelty and publication impact of iPS cells, sncRNAs, chromatin modification, and cancer stem cells.
  • Microproteins are identified as the most promising emerging field with high potential for significant discoveries and publications.

Conclusions:

  • Microproteins represent the next frontier in biomedical research, offering substantial opportunities for groundbreaking studies.
  • Researchers and journals should anticipate and focus on microprotein research for future high-impact contributions.