Related Experiment Video
Updated: May 15, 2026
07:51
Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
Published on: August 1, 2025
An evaluation of web-based clinical practice guidelines for managing problems associated with cannabis use
Melissa M Norberg1, Michael W Turner, Sally E Rooke
1University of New South Wales, National Cannabis Prevention and Information Centre, Randwick, Australia. m.norberg@unsw.edu.au
Journal of Medical Internet Research
|December 20, 2012
Summary
The quality of online clinical practice guidelines (CPGs) for cannabis use varies significantly. Treatment providers should be aware of this variability and developers should improve guideline reporting and applicability for better implementation.
Area of Science:
- Addiction Medicine
- Clinical Practice Guidelines
- Public Health
Background:
- Cannabis use is prevalent, with increasing development of online clinical practice guidelines (CPGs).
- The quality and accessibility of these online CPGs are not well understood.
- This study evaluates the methodological quality and provider perception of cannabis CPGs.
Purpose of the Study:
- To assess the adherence of online cannabis CPGs to methodological standards.
- To determine treatment providers' familiarity with and perceived quality of these guidelines.
Main Methods:
- Systematic search for online cannabis CPGs providing psychological interventions.
- Quality assessment of 7 identified guidelines using the Appraisal of Guidelines for Research and Evaluation (AGREE II) tool.
- Online survey of 166 Australian treatment providers assessing guideline familiarity and perceived quality.
Main Results:
- Guideline quality varied significantly, with lowest scores in rigor of development, applicability, and editorial independence.
- Treatment providers perceived all guidelines as acceptable quality, contrasting with AGREE II scores.
- Effective dissemination methods include peers, senior professionals, workshops, and internet; barriers include time, length, and theoretical conflicts.
Conclusions:
- CPG developers must enhance reporting on development, conflicts of interest, and applicability.
- Guideline length may hinder implementation; conciseness is recommended.
- Treatment providers must recognize the substantial variation in cannabis CPG quality.
Related Concept Videos
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
01:03Drug Control Governance: Regulatory Bodies and Their Impact
Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with a...
01:29Therapeutic Drug Monitoring: Affecting Factors
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
01:11Guidelines for Writing Outcome
When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care evaluation by...
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care evaluation by...