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Updated: May 15, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
[Is the diagnosis 'depression' still useful?]
Berend Terluin1, Marian J T Oud
1VU medisch centrum, EMGO-instituut, Amsterdam, the Netherlands. b.terluin@vumc.nl
Abstract:
The DSM diagnosis of depression is based solely on the presence of symptoms, without taking into account the context in which these symptoms have occurred. For this reason, the DSM diagnosis does not distinguish between sadness as a normal reaction to a painful loss and pathologically depressive reactions that are disproportionate to personal life events and circumstances. According to a group of mental health expert general practitioners, a true depressive disorder is characterized by a depression that has acquired a life of its own and is hard to control. This depression is severe, and is recognized by the patient as alien to his or her character. Loss of the ability to experience pleasure in ordinary things (anhedonia) and thoughts about death as an alternative for the torment experienced are often present. We recommend the diagnosis of depression be reserved for clearly pathologically depressive reactions that are also recognized as such by the patient.
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