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Updated: May 15, 2026

07:57
A New Method for Inducing a Depression-Like Behavior in Rats
Published on: February 22, 2018
[Is the diagnosis 'depression' still useful?]
Berend Terluin1, Marian J T Oud
1VU medisch centrum, EMGO-instituut, Amsterdam, the Netherlands. b.terluin@vumc.nl
Nederlands Tijdschrift Voor Geneeskunde
|December 20, 2012
Summary
The DSM diagnosis for depression needs improvement. It should differentiate normal sadness from pathological depression, focusing on patient-recognized, severe symptoms like anhedonia.
Area of Science:
- Psychiatry
- Clinical Psychology
- Mental Health
Context:
- Current Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria for depression rely solely on symptom presence.
- The DSM lacks differentiation between normal sadness and pathological depression based on context.
- This can lead to misdiagnosis of normal grief as a depressive disorder.
Purpose:
- To propose a refined diagnostic approach for depression.
- To distinguish between situational sadness and a distinct depressive disorder.
- To align diagnostic criteria with expert clinical judgment.
Summary:
- A true depressive disorder is characterized by severe, uncontrollable depression recognized by the patient as alien to their personality.
- Key indicators include anhedonia (loss of pleasure) and suicidal ideation.
- The diagnosis of depression should be reserved for pathological reactions acknowledged by the patient.
Impact:
- This approach could lead to more accurate depression diagnoses.
- It may improve treatment selection and patient outcomes.
- Enhances understanding of depressive disorders in clinical practice.
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