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[Targeted based therapies in metastatic breast cancer: future evolution]

Laure Belmondo1, Marc Montana, Christophe Curti

  • 1Service de la Pharmacie à Usage Intérieur, Hôpital Sainte Marguerite, Marseille, France. lbelmondo@hotmail.fr

Therapie
|December 20, 2012
PubMed

Insights

New targeted therapies like HER-2 dimerization inhibitors show promise for breast cancer but are often ineffective alone. This review highlights efficient targeted therapies and their combinations with cytotoxic molecules.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Context:

  • Cancerogenesis research has led to targeted therapies.
  • HER-2 dimerization inhibitors are a recent therapeutic class under investigation.
  • Monotherapy with these agents is often ineffective for breast cancer.

Purpose:

  • To review the most efficient targeted therapies for breast cancer.
  • To discuss the combination of targeted therapies with cytotoxic molecules.

Summary:

  • Targeted therapies, including HER-2 dimerization inhibitors, are being developed for cancer.
  • These therapies show limited efficacy as monotherapy.
  • Ongoing clinical trials evaluate their effectiveness in combination with other oncology treatments.

Impact:

  • Breast cancer remains a life-threatening disease.
  • This review provides insights into effective targeted therapies and their combinations.
  • Potential for improved breast cancer treatment strategies.

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