Related Experiment Video
Updated: May 15, 2026

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
Published on: July 3, 2020
Testing Hardy-Weinberg disequilibrium using the generalized linear model
1Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, USA. shizhong.xu@ucr.edu
Abstract:
Current methods for detecting Hardy-Weinberg disequilibrium (HWD) only deal with one locus at a time. We developed a method that can jointly detect HWD for multiple loci. The method was developed under the generalized linear model (GLM) using the probit link function. When applied to a single locus, the new method is more powerful than the exact test. When applied to two or more loci, the method can reduce false positives caused by linkage disequilibrium (LD). We applied the method to 24 single nucleotide polymorphism (SNP) markers of a single human gene and eliminated several false positive HWDs due to LD. We developed an R package 'hwdglm' for joint HWD detection, which can be downloaded from our personal website (www.statgen.ucr.edu).
Related Concept Videos
Hardy-Weinberg Principle
Test for Homogeneity
Genetic Drift
Mutation, Gene Flow, and Genetic Drift
Mechanistic Models: Compartment Models in Individual and Population Analysis
Wald-Wolfowitz Runs Test II
For binary data, runs are identified using symbols such as + and −, or equivalently, 1s and 0s. In...

