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Related Experiment Video

Updated: May 15, 2026

A Novel and Translational Rat Model of Concussion Combining Force and Rotation with In Vivo Cerebral Microdialysis
08:45

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Published on: July 12, 2019

Decrease in N-acetylaspartate following concussion may be coupled to decrease in creatine.

Roberto Vagnozzi1, Stefano Signoretti, Roberto Floris

  • 1Division of Neurotraumatology and Neuroradiology, Department of Biomedicine and Prevention, University of Rome "Tor Vergata," Italy.

The Journal of Head Trauma Rehabilitation
|December 20, 2012
PubMed
Summary
This summary is machine-generated.

Sport-related concussions in athletes can alter brain metabolism, affecting N-acetylaspartate (NAA) and creatine (Cr) levels. These metabolic changes may prolong recovery time and the resolution of clinical symptoms following head injury.

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Last Updated: May 15, 2026

A Novel and Translational Rat Model of Concussion Combining Force and Rotation with In Vivo Cerebral Microdialysis
08:45

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11:32

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09:49

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Published on: January 20, 2023

Area of Science:

  • Neuroscience
  • Sports Medicine
  • Biochemistry

Background:

  • Sport-related concussions are common injuries in athletes.
  • Understanding the metabolic changes post-concussion is crucial for recovery.
  • Proton magnetic resonance spectroscopy (MRS) can non-invasively assess brain metabolites.

Purpose of the Study:

  • To investigate the time-course changes in brain N-acetylaspartate (NAA), creatine (Cr), and choline (Cho) levels in athletes after a sport-related concussion.
  • To compare metabolite levels in concussed athletes with healthy controls.

Main Methods:

  • Eleven athletes with concussions and 11 age- and sex-matched controls participated.
  • Proton magnetic resonance spectroscopy (MRS) was used to measure NAA, Cr, and Cho levels.
  • Measurements were taken at 3, 15, 30, and 45 days post-injury.

Main Results:

  • The NAA/Cr ratio increased at 3 and 15 days post-concussion, then normalized by 30-45 days.
  • The NAA/Cho ratio decreased at 3, 15, and 30 days post-injury.
  • The Cho/Cr ratio significantly increased at 3 and 15 days post-injury, returning to normal by 30-45 days.

Conclusions:

  • Concussion in athletes is associated with altered brain metabolism, specifically affecting NAA and Cr levels.
  • These metabolic alterations may contribute to a prolonged recovery period and resolution of concussion symptoms.
  • Metabolite levels generally normalize within 45 days post-injury, suggesting a potential window for therapeutic intervention.