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Related Experiment Video

Updated: May 15, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

Second malignant neoplasms following radiotherapy.

Sanath Kumar1

  • 1Department of Radiation Oncology, Henry Ford Hospital, Detroit, MI 48202, USA. skumar4@hfhs.org

International Journal of Environmental Research and Public Health
|December 20, 2012
PubMed
Summary

Radiotherapy is common for cancer patients, but survivors face a risk of secondary cancers, especially after childhood treatment. Understanding radiation-induced malignancy is key to prevention.

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Cancer Epidemiology

Background:

  • Radiotherapy is a cornerstone of cancer treatment, utilized by over half of all cancer patients.
  • Long-term cancer survivors are increasingly monitored for secondary malignant neoplasms (SMN) due to radiation exposure.
  • The risk of SMN is notably elevated in survivors of childhood cancers.

Purpose of the Study:

  • To review the incidence, etiology, and risk factors associated with radiation-induced second malignant neoplasm (SMN).
  • To consolidate current understanding of SMN development following radiotherapy.
  • To inform strategies for the prevention and mitigation of radiation-induced cancers.

Main Methods:

  • Systematic literature review of studies on radiotherapy and secondary malignancies.
  • Analysis of epidemiological data on SMN incidence across various organs.
  • Examination of etiological factors and dose-response relationships for radiation-induced cancers.

Main Results:

  • The incidence of SMN is a significant concern for cancer survivors treated with radiotherapy.
  • Childhood cancer survivors exhibit a particularly high risk for developing SMN.
  • The precise mechanisms and dose-response patterns for radiation-induced malignancy require further elucidation.

Conclusions:

  • Effective strategies for the prevention and mitigation of radiation-induced SMN are crucial.
  • Further research into the mechanisms and risk factors is needed to improve long-term cancer survivor outcomes.
  • Addressing the risk of SMN is essential for enhancing the quality of life for cancer survivors.

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Last Updated: May 15, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017