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CLIP Test: a new fast, simple and powerful method to distinguish between linked or pleiotropic quantitative trait

I David1, J-M Elsen, D Concordet

  • 1INRA UR631 SAGA, F-31326, Castanet-Tolosan, France. Ingrid.david@toulouse.inra.fr

Heredity
|December 20, 2012
PubMed

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Alleles are different forms of the same gene. Humans and other diploid organisms inherit two alleles of every gene, one from each parent.
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Alleles are different forms of the same gene. Humans and other diploid organisms inherit two alleles of every gene, one from each parent.
Multiple Comparison Tests01:13

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Multiple comparison test, abbreviated as MCT, is a post hoc analysis generally performed after comparing multiple samples with one or more tests. An MCT will help identify a significantly different sample among multiple samples or a factor among multiple factors.
It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...
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Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
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