Related Experiment Video
Updated: May 15, 2026

International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure
Published on: March 12, 2020
Prevalence and factors associated with thoracic alterations in infants born prematurely
Josy Davidson1, Kessey Maria B Garcia, Liu C Yi
1Neonatal Division of Medicine, Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Insights
Thoracic musculoskeletal alterations are common in premature infants. These changes are linked to lung conditions like respiratory distress syndrome and bronchopulmonary dysplasia, as well as a low length-to-age ratio.
Area of Science:
- Pediatrics
- Musculoskeletal Health
- Neonatology
Background:
- Premature infants often experience developmental challenges.
- Thoracic musculoskeletal alterations can impact respiratory function and overall growth.
Purpose of the Study:
- To determine the prevalence of thoracic musculoskeletal alterations in premature infants.
- To identify factors associated with these alterations in the first year of life.
Main Methods:
- Cross-sectional study of infants born prematurely (birth weight < 2,000 g).
- Physical examinations by two independent physiotherapists assessed thoracic retractions and shoulder elevation.
- Univariate and multiple logistic regression analyses identified associated factors.
Main Results:
- High prevalence of thoracic alterations: 66.9% and 68.6% detected by two physiotherapists (kappa = 0.77).
- Associated factors included respiratory distress syndrome (OR=3.25), bronchopulmonary dysplasia (OR=11.14), and low length/age ratio (OR=4.57).
Conclusions:
- Thoracic musculoskeletal alterations are highly prevalent in premature infants.
- Pulmonary disease and a low length/age ratio are significantly associated with these alterations.
Objective:
To determine the prevalence of thoracic musculoskeletal alterations and associated factors in infants born prematurely.
Methods:
This was a cross sectional study with infants in the first year of age, born prematurely with birth weight < 2,000 g, who were followed up at the Premature Clinic from February, 2007 to December, 2008. Exclusion criteria were: major congenital malformations as defined by the Centers for Disease Control and Prevention (CDC), grade III/IV intraventricular hemorrhage, or periventricular leucomalacia. Physical examinations performed independently by two physiotherapists were used to assess shoulder elevation and thoracic retractions. Comparisons between groups were performed using the chi-squared test or Fisher's exact test for categorical variables, and Mann-Whitney's test or Student's t-test were used for continuous variables. Interobserver reliability between the two physiotherapists was assessed by the kappa coefficient. Variables associated with these thoracic musculoskeletal alterations were studied by univariate and multiple logistic analyses. Statistical differences were considered significant when p < 0.05. This study was approved by the ethical committee of the institution, and parents/guardians signed an informed consent.
Results:
121 infants with a gestational age of 31.1 ± 2.8 weeks and birth weight of 1,400 ± 338 g were included. Thoracic alterations were detected by Physiotherapist 1 in 81 (66.9%) infants, and in 83 (68.6%) by Physiotherapist 2 (kappa coefficient = 0.77). By multivariate logistic regression analysis, factors associated with thoracic musculoskeletal alterations were: respiratory distress syndrome (odds ratio [OR] = 3.246, 95% confidence interval [CI]: 1.237-8.732), bronchopulmonary dysplasia (OR = 11.138, 95% CI: 1.339-92.621), and low length/age ratio (OR = 4.571, 95% CI: 1.371-15.242).
Conclusion:
The prevalence of thoracic alterations was high in infants born prematurely, and was associated with pulmonary disease and low length/age ratio.
Related Concept Videos
Factors Affecting Pulmonary Ventilation
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Respiratory System Abnormal Finding I: Inspection and Percussion
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...
Physical Assessment of the Respiratory Tract II: Inspection
Chest Configuration
The chest configuration can...
Pneumothorax II: Pathophysiology
Development of the Oral Microbiota
Pneumothorax-II
Clinical Manifestations:

