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Updated: May 15, 2026
08:42
Myo-mechanical Analysis of Isolated Skeletal Muscle
Published on: February 22, 2011
[Steroid-induced myopathy]
Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|December 20, 2012
Summary
Long-term high-dose glucocorticoid use can cause steroid myopathy, leading to muscle weakness. Vitamin D and amino acid mixtures show promise in preventing and treating this condition.
Area of Science:
- Endocrinology and Muscle Physiology
- Pharmacology of Glucocorticoids
Context:
- Glucocorticoids are widely used for their anti-inflammatory and immunosuppressive effects.
- Long-term administration, especially at high doses, is associated with significant side effects.
- Steroid myopathy is a recognized complication affecting skeletal muscles.
Purpose:
- To summarize the physiological effects of glucocorticoids on muscle tissue.
- To describe the clinical manifestations and mechanisms of steroid myopathy.
- To review current strategies for prevention and treatment, highlighting novel therapeutic agents.
Summary:
- Glucocorticoids inhibit protein synthesis and promote catabolism, leading to muscle atrophy and weakness.
- Manifestations include proximal lower limb weakness, respiratory muscle impairment, and dysphonia.
- Prevention involves judicious glucocorticoid use, alternating regimens, and physical activity.
Impact:
- Identifies key therapeutic targets for mitigating glucocorticoid-induced muscle damage.
- Provides evidence for the efficacy of vitamin D and amino acids in managing steroid myopathy.
- Informs clinical practice regarding the safe and effective use of glucocorticoids.
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