Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 15, 2026

Multimodal Analysis of Microplastics in Drinking Water using a Silicon Nanomembrane Analysis Pipeline
09:10

Multimodal Analysis of Microplastics in Drinking Water using a Silicon Nanomembrane Analysis Pipeline

Published on: June 13, 2025

Biomimetic antireflective silicon nanocones array for small molecules analysis.

Yandong Wang1, Zhoufang Zeng, Jie Li

  • 1State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, People's Republic of China.

Journal of the American Society for Mass Spectrometry
|December 20, 2012
PubMed
Summary

Biomimetic antireflective silicon nanocones enhance mass spectrometry by optimizing laser energy absorption for precise small molecule detection. This improves the analysis of peptides, amino acids, drugs, and carbohydrates without low-mass interference.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Study on determination of eight metal elements in Hainan arecanut leaf by flame atomic absorption spectrophotometry].

Guang pu xue yu guang pu fen xi = Guang pu·2009
Same author

Pseudonocardia endophytica sp. nov., isolated from the pharmaceutical plant Lobelia clavata.

International journal of systematic and evolutionary microbiology·2009
Same author

Highly selective biotransformation of ginsenoside Rb1 to Rd by the phytopathogenic fungus Cladosporium fulvum (syn. Fulvia fulva).

Journal of industrial microbiology & biotechnology·2009
Same author

Synthesis and resolution of planar-chiral ruthenium-palladium complexes with ECE' pincer ligands.

Chemistry (Weinheim an der Bergstrasse, Germany)·2009
Same author

Human DNA sequences: more variation and less race.

American journal of physical anthropology·2009
Same author

Determination of organophosphorus pesticides in underground water by SPE-GC-MS.

Journal of chromatographic science·2009

Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Nanotechnology

Background:

  • Mass spectrometry is crucial for analyzing small molecules.
  • Laser desorption/ionization (LDI) efficiency depends on laser energy absorption and distribution.
  • Current LDI methods face challenges with sensitivity and interference, especially for low-mass analytes.

Purpose of the Study:

  • To investigate the role of absorbed laser energy and its distribution in LDI using biomimetic antireflective silicon nanocones.
  • To optimize the antireflective features of silicon nanocone arrays for enhanced LDI performance.
  • To demonstrate the capability of the optimized array for sensitive and interference-free detection of various small molecules.

Main Methods:

  • Fabrication of biomimetic antireflective silicon nanocones arrays with precisely controlled features.

More Related Videos

Porous Silicon Microparticles for Delivery of siRNA Therapeutics
08:31

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
09:28

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

Related Experiment Videos

Last Updated: May 15, 2026

Multimodal Analysis of Microplastics in Drinking Water using a Silicon Nanomembrane Analysis Pipeline
09:10

Multimodal Analysis of Microplastics in Drinking Water using a Silicon Nanomembrane Analysis Pipeline

Published on: June 13, 2025

Porous Silicon Microparticles for Delivery of siRNA Therapeutics
08:31

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
09:28

Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes

Published on: January 10, 2017

  • Systematic investigation of laser energy absorption and distribution by varying antireflective array parameters.
  • Application of the optimized silicon nanocone array in mass spectrometry for the analysis of peptides, amino acids, drug molecules, and carbohydrates.

    • Main Results:

    • Optimized antireflective silicon nanocone arrays effectively channel absorbed laser energy into the desorption/ionization process.
    • The optimized array significantly enhances the sensitivity and reduces interference in LDI mass spectrometry.
    • Successful detection of diverse small molecules, including peptides, amino acids, drug molecules, and carbohydrates, in the low-mass region without interference.

    Conclusions:

    • Biomimetic antireflective silicon nanocone arrays represent a significant advancement for mass spectrometry analysis.
    • Optimizing laser energy absorption via these nanostructures is key to improving LDI efficiency.
    • The developed silicon array offers a robust platform for sensitive and selective small molecule detection.