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Treatment of arterial remodeling in essential hypertension

Marie Briet1, Ernesto L Schiffrin

  • 1Assistance Publique des Hôpitaux de Paris, Hôpital européen Georges Pompidou and INSERM CIC 9201, Université Paris Descartes, Paris, France.

Current Hypertension Reports
|December 20, 2012
PubMed

Insights

Essential hypertension affects blood vessels, but treatments like renin-angiotensin-aldosterone system inhibitors and lifestyle changes can improve vascular remodeling. New therapies are also being evaluated for their impact on vascular health.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Hypertension Research

Background:

  • Essential hypertension is linked to significant vascular remodeling, affecting both large and small vessels.
  • This vascular remodeling has a direct impact on the cardiovascular prognosis of hypertensive patients.

Purpose of the Study:

  • To explore the effects of antihypertensive therapies and lifestyle modifications on vascular remodeling in essential hypertension.
  • To review emerging pharmacological and device-based treatments for their potential to improve vascular remodeling.

Main Methods:

  • Analysis of longitudinal follow-up data from hypertensive patients.
  • Review of studies on renin-angiotensin-aldosterone system inhibitors and their impact on arterial stiffness.
  • Evaluation of lifestyle modifications such as exercise and weight reduction.
  • Assessment of novel antihypertensive agents and devices under current investigation.

Main Results:

  • Large arterial stiffness reduction observed in hypertensive patients, partly independent of blood pressure changes, suggesting specific drug effects.
  • Renin-angiotensin-aldosterone system inhibitors demonstrate significant effects on vascular remodeling.
  • Lifestyle modifications including exercise and weight reduction positively impact both large and small vascular remodeling.

Conclusions:

  • Antihypertensive therapies, particularly those targeting the renin-angiotensin-aldosterone system, offer benefits beyond blood pressure reduction by improving vascular remodeling.
  • Lifestyle interventions are crucial for improving vascular health in hypertensive individuals.
  • Novel pharmacological and device-based treatments show promise for further enhancing vascular remodeling and cardiovascular outcomes in hypertension.

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