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09:09
An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
Published on: April 18, 2016
Crosstalk between neutrophils and dendritic cells: a context-dependent process.
Steffen Schuster1, Benjamin Hurrell, Fabienne Tacchini-Cottier
11.WHO Immunology Research and Training Center, University of Lausanne, Boveresses 155, 1066 Epalinges, Switzerland. fabienne.tacchini-cottier@unil.ch.
Journal of Leukocyte Biology
|December 20, 2012
Summary
Neutrophils (a type of white blood cell) rapidly respond to infection and can regulate immune responses. Their interactions with dendritic cells (DCs) significantly impact infection outcomes.
Area of Science:
- Immunology
- Cellular Biology
- Infectious Disease
Background:
- Neutrophils are rapidly recruited to infection sites and draining lymph nodes (dLNs).
- Beyond microbial killing, neutrophils exhibit immunoregulatory functions, influencing other leukocytes like NK cells, B cells, and dendritic cells (DCs).
- Dendritic cells (DCs) are professional antigen-presenting cells crucial for initiating and regulating immune responses.
Purpose of the Study:
- To review recent advancements in understanding neutrophil immunoregulatory roles.
- To explore the crosstalk between neutrophils and dendritic cells (DCs).
- To discuss how neutrophil regulation of DCs impacts adaptive immunity and infection outcomes.
Main Methods:
- Literature review of recent progress in neutrophil-DC interactions.
- Synthesis of findings presented at the "Neutrophil in Immunity" symposium (June 2012).
Main Results:
- Neutrophils can influence the activation of various immune cells, including DCs.
- Neutrophil-DC crosstalk can directly affect antigen-specific immune responses.
- Neutrophil regulatory actions on DCs may vary based on the pathogen and host environment.
Conclusions:
- Neutrophil-dendritic cell interactions are critical for shaping adaptive immunity during infection.
- Understanding these interactions provides insights into infection outcomes.
- Context-dependent neutrophil functions highlight their complex role in immunity.
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