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Updated: May 15, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Large right atrial thrombus associated with central venous catheter requiring open heart surgery
Nasir Hussain1, Paul Eric Shattuck, Mourad Hussein Senussi
1Department of Internal Medicine, Saint Joseph Hospital, Resurrection Health Care, 2900 North Lake Shore Drive, Chicago, IL 60657, USA.
Insights
Central venous catheter-associated right atrial thrombosis (CRAT) poses significant mortality risks. Successful open heart surgery for a large CRAT, following medical treatment failure, highlights early detection and surgical intervention importance.
Area of Science:
- Cardiology
- Vascular Surgery
- Nephrology
Background:
- Central venous catheters (CVCs) are widely used in clinical settings.
- CVC-related right atrial thrombosis (CRAT) presents variable incidences but carries high mortality risks, especially in non-hemodialysis patients (>40%).
- Pathogenic mechanisms for CRAT include mechanical irritation, clot propagation, hypercoagulability, and altered right atrial hemodynamics.
Purpose of the Study:
- To report a case of successful open heart surgery for a large CRAT in an asymptomatic patient.
- To emphasize the importance of early CRAT detection and its impact on prognosis.
- To highlight the role of transesophageal echocardiography in CRAT diagnosis and treatment guidance.
Main Methods:
- Case report of a 59-year-old male undergoing preoperative evaluation for kidney transplant.
- Diagnosis of a large CRAT via transesophageal echocardiography.
- Successful treatment with open heart surgery after medical management failure.
Main Results:
- The patient, initially asymptomatic, was successfully treated with open heart surgery for a large CRAT.
- Early detection of CRAT was crucial for a favorable outcome, avoiding catastrophic complications.
- Transesophageal echocardiography proved vital in detecting the thrombus and potentially guiding treatment decisions.
Conclusions:
- Early detection of CRAT is critical for improving patient prognosis.
- Open heart surgery can be an effective treatment for large CRAT, particularly after medical treatment failure.
- Transesophageal echocardiography plays a key role in diagnosing CRAT and informing treatment strategies.
Abstract:
Central venous catheters (CVC) are used commonly in clinical practice. Incidences of CVC-related right atrial thrombosis (CRAT) are variable, but, when right atrial thrombus is present, it carries a mortality risk of 18% in hemodialysis patients and greater than 40% risk in nonhemodialysis patients. Different pathogenic mechanisms have been postulated for the development of CRAT, which includes mechanical irritation of the myocardial wall, propagation of intraluminal clot, hypercoagulability, and hemodynamics of right atria. Presentation of CRAT may be asymptomatic or may be associated with one of the complications of CRAT like pulmonary embolism, systemic embolism, infected thrombi, or hemodynamic compromise. There are no established treatment guidelines for CRAT. We describe an interesting case of a 59-year-old asymptomatic male successfully treated with open heart surgery after failure of medical treatment for a large CRAT discovered during a preoperative evaluation for a kidney transplant. Our case underscores that early detection of CRAT may carry a favorable prognosis as opposed to waiting until catastrophic complications arise. It also underscores the importance of transesophageal echocardiography in the detection of thrombus and perhaps guides clinicians on which treatment modality to be used according to the size of the thrombus.
Related Concept Videos
Venous Thrombosis III: Interprofessional Care
Cardiac Catheterization II: Right Heart Catheterization
Cardiac Catheterization III: Left Heart Catheterization
Venous Thrombosis I: Introduction
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Cardiac Catheterization I: Pre-Procedure Overview

