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Hyperfibrinolysis after parapelvic cyst surgery: A case report
Chun-Hua Tang1, Li-Jing Shen, Qiang Gao
1Department of Urology, Songjiang Hospital Affliated to First Hospital of Shanghai, Songjiang;
Experimental and Therapeutic Medicine
|December 20, 2012
Summary
This study details treating hyperfibrinolysis, a bleeding disorder, after surgery. Prompt diagnosis using D-dimer and fibrin degradation product levels, followed by p-aminomethylbenzoic acid (PAMBA) treatment, stabilized the patient effectively.
Area of Science:
- Urology
- Hematology
- Surgical Complications
Background:
- Hyperfibrinolysis, a bleeding disorder, can occur post-surgery.
- Delayed hemorrhage following surgical procedures requires careful consideration.
- Accurate diagnosis is crucial for effective management of bleeding complications.
Purpose of the Study:
- To describe the diagnosis and treatment of hyperfibrinolysis in a patient experiencing delayed post-surgical hemorrhage.
- To evaluate the efficacy of anti-fibrinolytic therapy in managing this condition.
Main Methods:
- Diagnosis involved intravenous pyelogram (IVP), computed tomography (CT), and retrograde pyelography.
- Monitoring of hemoglobin (Hb), D-dimer, and fibrin degradation product (FDP) levels.
- Treatment with erythrocyte suspension transfusion and p-aminomethylbenzoic acid (PAMBA).
Main Results:
- The patient presented with shock and severe anemia (Hb 62.2 g/l) post-surgery.
- Elevated D-dimer and FDP levels indicated hyperfibrinolysis.
- PAMBA treatment led to a steady increase in Hb levels and clinical stabilization.
Conclusions:
- Delayed post-surgical hemorrhage can manifest as hyperfibrinolysis.
- Monitoring FDP and D-dimer levels aids in rapid diagnosis.
- Anti-fibrinolytic therapy with PAMBA is a safe and effective treatment for hyperfibrinolysis-induced hemorrhage.